Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

Igor Beseda; Laszlo Czollner; Priti S Shah; Rupesh Khunt; Rawindra Gaware; Paul Kosma; Christian Stanetty; Maria Carmen Del Ruiz-Ruiz; Hassan Amer; Kurt Mereiter; Thierry Da Cunha; Alex Odermatt; Dirk Classen-Houben; Ulrich Jordis

doi:10.1016/j.bmc.2009.10.036

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

Bioorg Med Chem. 2010 Jan 1;18(1):433-54. doi: 10.1016/j.bmc.2009.10.036. Epub 2009 Oct 23.

Authors

Igor Beseda¹, Laszlo Czollner, Priti S Shah, Rupesh Khunt, Rawindra Gaware, Paul Kosma, Christian Stanetty, Maria Carmen Del Ruiz-Ruiz, Hassan Amer, Kurt Mereiter, Thierry Da Cunha, Alex Odermatt, Dirk Classen-Houben, Ulrich Jordis

Affiliation

¹ Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.

PMID: 19914836
DOI: 10.1016/j.bmc.2009.10.036

Abstract

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
11-beta-Hydroxysteroid Dehydrogenases / metabolism*
Crystallography, X-Ray
Glycyrrhetinic Acid / analogs & derivatives*
Glycyrrhetinic Acid / chemical synthesis
Glycyrrhetinic Acid / pharmacology*
Humans
Metabolic Diseases / drug therapy*
Models, Molecular

Substances

11-beta-Hydroxysteroid Dehydrogenases
Glycyrrhetinic Acid